Roman M. Natoli

A Prospective Randomized Trial to Assess Early versus Delayed Weight Bearing Following Operatively Treated Ankle Fractures in the United States

OBJECTIVES: To determine the safety of early versus delayed weight bearing and effectiveness for improving return-to-work following ankle fracture repair. METHODS: Design : Prospective randomized study. Setting: 19 United States Trauma Centers Patient Selection Criteria: Adult pa...

Contemporary Update on Fracture-Related Infection: A Multidisciplinary Approach to Evaluation, Prevention, and Treatment

Fracture-related infection (FRI) can be a devastating complication after fracture surgery and presents many challenges for the treating clinician. A consensus definition including clinical, radiographic, and laboratory components has standardized the diagnosis and investigative e...

Halicin‑Rifampicin Combinations Are More Effective Than Monotherapy Against Biofilm‑Residing Staphylococcus Aureus and Prevent Emergence of Rifampicin Resistance

Background: Biofilms shield bacteria from immune defenses and antibiotics, contributing to implant-associated infections, particularly those caused by Staphylococcus aureus (S. aureus). Halicin, a repurposed antimicrobial with broad-spectrum activity, has shown promise against pl...