Roman Jerala

Validation and analysis of 12,000 AI-driven CAR-T designs in the Bits to Binders competition

Abstract Artificial intelligence (AI) methods for proteins have advanced rapidly, improving structure prediction and design, particularly for de novo binders. However, most evaluations emphasize binding affinity rather than higher-order biological function. We present Bits to Bin...

Small Activating RNAs: A Curated Database and an Overview of Rational Design Principles

RNA activation (RNAa), mediated by small activating RNAs (saRNAs), upregulates endogenous gene expression through recruitment of the Argonaute proteins to the promoter, natural antisense transcripts, or other noncoding RNAs. This mechanistically distinct modality addresses an unm...