Román Fischer

A critical role for the ER membrane complex (EMC) in lipid homeostasis

Abstract The ER membrane complex (EMC) facilitates insertion of integral membrane proteins into the endoplasmic reticulum (ER) lipid bilayer. Recent years have seen significant progress in understanding the structural aspects of EMC, but the identity of EMC-client proteins and EM...

Spatiotemporal co-regulation of IL2 and TCR receptors reveals early antigen-driven synaptic synergy in human CD8+ T cells

Abstract Interleukin 2 (IL2) promotes T cell proliferation and differentiation, making it a central target in immunotherapies. Following antigen recognition, IL2 receptor (IL2R) signaling polarizes towards the immunological synapse (IS). However, how IL2 function is integrated du...

Lysosomal signaling pathways influence heart rhythm, and regulate atrial function

AIMS: In the heart, endogenous nicotinic acid adenine dinucleotide phosphate (NAADP) triggers lysosomal calcium (Ca2+) release to augment sarcoplasmic reticulum (SR) Ca2+ sequestration, producing larger Ca2+ transients. However, the role of lysosomal Ca2+ signals in pacemaker act...