Rokas Grinkevičius

IL1B rs1143634 genotype and differential cancer-specific survival by neoadjuvant strategy in locally advanced rectal cancer: an exploratory analysis of a prospective randomized noninferiority trial

Abstract Background Locally advanced rectal cancer (LARC) treatment selection between neoadjuvant intensified chemotherapy (NIC) and standard chemoradiotherapy (CRT) lacks validated predictive biomarkers. Interleukin-1β (IL1B) polymorphisms modulate IL-1β expression and may influ...