Rohit V. Pappu

Unphosphorylated tyrosines mediate PD-1 inhibition of T cell signaling condensate formation

T cell receptor (TCR) engagement stimulates formation of a biomolecular condensate, including the scaffold protein linker of activated T cells (LAT). We investigated whether the immune-inhibitory receptor programmed cell death protein 1 (PD-1) inhibits by impeding TCR-induced LAT...