Roberto Gramignoli

Adiponectin-enriched liver-derived ECM attenuates fibrogenic features of activated hepatic stellate cells in a multicellular 3D model

Abstract Background Adiponectin (ADPN), an adipocytokine expressed in multiple tissues including the liver by quiescent hepatic stellate cells (HSCs) has recognized antifibrotic properties. However, most studies rely on simplified 2D systems that fail to capture the liver microen...