Robert Zimmermann

A nutrient-sensitive CPT1C-ABHD6 axis regulates BMP homeostasis and endolysosomal function in hypothalamic neurons

The endolysosomal system is central to neuronal homeostasis, yet how nutrient sensing regulates endolysosomal lipids remains poorly understood. Bis(monoacylglycero)phosphate (BMP), a signature phospholipid of late endosomes, is required for intraluminal vesicle formation, cholest...