Robert Neil Kelsh

Intrinsic noise reduces fluctuation frequencies in a cross-repressilator model motivated by stem cell differentiation

The dynamical effects of intrinsic noise in gene regulatory networks (GRNs) can be significant when the number of molecules is low. In previous work, we proposed a new conceptual model, comprising a network of three transcription factors (TFs) that mutually inhibit each other (i....

MIT / TFE family transcription factors, Mitf and Tfec, redundantly promote pigment cell differentiation and retinal epithelium pigmentation in teleosts

BACKGROUND: Transcription factors of the MIT/TFE family-mitfa, mitfb, and tfec-play essential roles in specifying pigment cells derived from neural crest cells in vertebrates. In teleosts, which possess multiple pigment cell types, these factors exhibit partially redundant but la...