Robert K. Wayne

First genomic evidence of inbreeding in South American pumas and the role of Andean climate history in shaping genetic diversity

Abstract Climatic oscillations in the Andes have repeatedly reshaped habitats over millions of years, yet their long-term genomic consequences for carnivores with broad geographic distributions remain unclear. Given the long evolutionary history of pumas ( Puma concolor ) in Sout...

The distribution of fitness effects of nonsynonymous mutations varies phylogenetically across animals

The distribution of fitness effects (DFE) describes the selection coefficients of newly arising mutations and fundamentally influences population genetic processes. However, the extent and mechanisms of differences in the DFE for non-synonymous mutations have not been systematica...