Robert H. Tukey

Regulation of DiverseEndogenous Metabolic and SignalingPathways by UDP-Glucuronosyltransferases (UGTs) Revealed by Metabolomicsof Knockout Mice

Abstract Uridine 5′-diphospho-glucuronosyltransferase (UGT) enzymes play a critical role in hepatic and other metabolism of endogenous and exogenous small molecules. The addition of glucuronic acid via UGT increases the polarity and subsequent solubility of small molecules, helpi...