Robert H. E. Friesen

Antibody Hotspot-Centric de Novo Design of Peptide Inhibitors of Influenza A Virus Membrane Fusion

Abstract Here we report the applicability of a hotspot-centric approach for de novo computational design of l-peptides based on crystal structures of antigen–antibody complexes. Broadly neutralizing antibodies (bnAbs) FI6v3 and CR9114, which target influenza A virus hemagglutinin...