Robert Clarke

Proteome-wide genetic analyses identify ASGR1 as a potential biomarker linking smoking with ischemic heart disease

Abstract Tobacco smoking increases the risk of multiple diseases, but the biological mechanisms involved remain incompletely understood. Here we characterize smoking-related protein profiles to identify potentially causal biomarkers mediating smoking’s effects. In European-ancest...

Concordance of genetic determinants of acute coronary artery disease between European and Chinese populations

AIMS: This study examined the concordance of associations of single nucleotide polymorphisms (SNPs) for acute coronary artery disease (CAD) discovered in Europeans with acute CAD, chronic ischaemic heart disease (IHD) or stroke in Chinese adults. METHODS: In a nested case-control...