Robert Bals

Safety and pharmacokinetics of inhaled aloxistatin: A first‐in‐human phase 1 dose escalation trial

Aims Aloxistatin (E64d) is a membrane‐permeable cysteine protease inhibitor prodrug that is converted by esterases to the active metabolite E64c (loxistatin). This first‐in‐human study evaluated the safety, tolerability and pharmacokinetics of single ascending doses of inhaled E6...

Visual feedback using electrical impedance tomography during inhalation therapy for chronic obstructive lung disease: a pilot study

Abstract Airflow limitation and hyperinflation contribute to increased respiratory workload and dyspnea in COPD. Inhalation therapy plays a crucial role, but its effectiveness depends on correct technique. Electrical impedance tomography (EIT) offers real-time visualization of ve...