Robert A. Gatenby

In vivo Tracking of Clonal Dynamics in UV-Induced Skin Carcinogenesis Reveals Tumor Development from Goliath Clades

Abstract While the genetic paradigm of cancer is powerful, it remains incomplete. For example, high mutational burdens are commonplace in homeostatically-stable epithelia, but the presence of driver mutations alone does not result in cancer. Here, we revealed additional factors c...

Fisher Information Limits on Genetic Stability, Diversity, and Regulation

Abstract Life and evolution require precise yet imperfect transmission of genetic information across generations. Accurate transmission maintains the genetic blueprint for phenotypes that succeed in current conditions, while some transmission error is necessary to generate herita...