Robert A. Gatenby

Density dependence and evolvability limit adaptive therapy in non-small cell lung cancer mouse model

Abstract Using NSG mice grafted with H3122 non-small cell lung cancer cells, we compared outcomes from (1) continuous therapy with alectinib, (2) adaptive therapy where alectinib was cycled on and off based on a mouse’s tumor burden, and (3) no treatment. Adaptive therapy has pro...