R.K. Bedi

Recognition Loop Dynamics Differentiates m6A-mRNA Reader Domains of YTHDF Proteins

Abstract The three human YTH-domain family proteins (YTHDF1, YTHDF2, and YTHDF3) are highly homologous and recognize the N6-methyladenosine (m6A) modification of mRNA with essentially identical binding modes and affinities. This homogeneity challenges the well-established view th...