Richard S. Lewis

Structural rearrangements underlying the activation of STIM1 by ER calcium depletion

ABSTRACT In resting cells, STIM1, the dimeric ER Ca 2+ sensor that controls store-operated Ca 2+ entry (SOCE), is held in a Ca 2+ -bound inactive state by multiple intramolecular restraints, or brakes. Receptor-evoked release of Ca 2+ from the ER causes a large conformational cha...