Richard Emsley

A practical framework for exploring non-linear dose–response using adherence data in complex interventions

Abstract Background Randomised trials of complex interventions commonly estimate the effect of being offered treatment using intention-to-treat (ITT) analyses. However, in many settings, particularly psychological therapies, participants adhere to varying amounts of treatment. Es...

Group sequential designs and a sample size reestimation approach for partially nested trials

Abstract Background Randomized controlled trials are the gold standard for evaluating interventions. For individually randomized trials, clustering can exist in the intervention arm but not the control arm when the intervention is delivered by study personnels and/or in a group s...