Richard E. Carson

Evaluation of an image-derived input function and population-based metabolite correction for quantification of synaptic density with [18F]SynVesT-1 and PET in male and female rats

Positron emission tomography (PET) quantification of radiotracers targeting synaptic vesicle glycoprotein 2A (SV2A), such as [ 18 F]SynVesT-1, requires arterial blood sampling and metabolite analysis to derive an arterial input function (AIF). However, arterial blood sampling is...