Richard David Tilley

Toward Accurate Molecular Counting in EC-STORM via Reversible Stochastic Dye Switching

Abstract Molecular counting using stochastic optical reconstruction microscopy (STORM), is often limited by random fluorophore reblinking, which makes repeated localization events hard to assign to the same or different molecules. Here, we turn reblinking from a source of uncerta...

Electrochemical DNA Biosensors Formed from Self-Assembled Monolayers of Thiolated DNA and Mercaptohexanol: What We Know About This Interface

Abstract Alkanethiol self-assembled monolayers have dominated methods for forming nucleic acid-modified functional interfaces on gold nanoparticles and electrodes due to the ease and spontaneous nature of gold–sulfur bond formation. In particular, an interface composed of DNA mod...