Richard A. Miller

Regulation of alanine glutamine asparagine catabolism is common to mouse models that extend lifespan

Previous work has shown that three interventions that extend mouse lifespan (acarbose, canagliflozin, or calorie restricted diet) as well as two genetic models (Snell and GHRKO) down-regulate MEK1-ERK and mTOR signaling and activate chaperone-mediated autophagy. Because of the co...