Reuben S. Maghembe

Distinct transcriptional remodeling of immune and metabolic pathways in severe undernutrition during latent tuberculosis infection does not consistently predict tuberculosis progression across independent cohorts

Background: Undernutrition increases tuberculosis (TB) risk, but whether severe undernutrition during latent TB infection (LTBI) produces blood transcriptional changes that resemble active disease or identify future TB remains unclear. Methods: We reanalyzed whole-blood RNA seque...

Evidence status of capsule-resolved phage recognition in multidrug-resistant Klebsiella pneumoniae: receptor specificity, depolymerase coverage, and precision phage therapy readiness

Multidrug-resistant Klebsiella pneumoniae has become a major test case for precision antibacterial therapy because its clinical success combines antimicrobial resistance, capsular immune evasion, biofilm formation, and rapid surface-antigen diversification. Bacteriophages and pha...

External transportability of bacterial- and viral-associated host-response modules across public transcriptomic cohorts

Objectives To determine whether bacterial- and viral-associated whole-blood host-response modules discovered in GSE211567 retain their prespecified directions when applied unchanged to two external cohorts, including a second cross-platform cohort, and to quantify their robustnes...