Renato Pascale

Reducing antibiotic burden in gram-negative bacteraemia: duration optimization and early oral transition

PURPOSE OF REVIEW: Gram-negative bloodstream infections have traditionally been managed with prolonged and intravenous antibiotic therapy. This review aims to summarize the evidence supporting strategies to reduce antibiotic burden through shorter treatment durations and/or oral...

Risk factors for treatment failure of surgical site deep infections following spinal instrumentation: multicentre observational study (DeFEndO study)

Introduction : To describe the characteristics and outcome of patients diagnosed with deep surgical-site infections following spinal instrumentation (DSIIs) and to investigate risk factors for treatment failure including antimicrobial treatment duration as the main exposure. Mate...