Ren Zhong-Lu

Synthetic lethal screens reveal p300/CBP as a vulnerability for GNAQ-driven uveal melanomas

Abstract Uveal melanoma is the most common intraocular cancer in adults, driven by activating mutations in GNAQ or GNA11 , which encode the G proteins Gαq and Gα11. Currently, therapeutic options for uveal melanoma, particularly metastatic uveal melanoma, remain limited. Through...