Reisa Anne Sperling

Network Localization of Anxiety as an Early Manifestation of Alzheimer's Disease-related Neurodegeneration

Objective Anxiety is a prominent neuropsychiatric symptom in preclinical Alzheimer's disease (AD), but the neural circuitry linking anxiety and AD remains uncharacterized. We assessed whether anxiety in preclinical AD is independently associated with AD-related neurodegeneration...

Cerebral microhemorrhage and cognition in preclinical Alzheimer’s disease

BACKGROUND: Clarifying whether incident cerebral microhemorrhages (CMHs) contribute to early cognitive or functional decline is increasingly important in the context of anti-amyloid therapies. OBJECTIVE: To determine whether incident CMHs are associated with longitudinal changes...