Ram W. Sabnis

Novel Compounds as TREM2 Agonists for Treating Parkinson’s Disease, Alzheimer’s Disease, Amyotrophic Lateral Sclerosis, Frontotemporal Dementia, Nasu-Hakola Disease, and Stroke

Abstract Provided herein are novel compounds as TREM2 agonists, pharmaceutical compositions, use of such compounds in treating Parkinson’s disease, Alzheimer’s disease, amyotrophic lateral sclerosis, frontotemporal dementia, Nasu-Hakola disease and stroke, and processes for prepa...

Novel Aminocyclohexenyl-6,6-bicyclic Compounds as 5-HT2A Receptor Agonists for Treating Depression, Anxiety, Substance Abuse, and Headaches

Abstract Provided herein are novel aminocyclohexenyl-6,6-bicyclic compounds as 5-HT2A receptor agonists, pharmaceutical compositions, use of such compounds in treating depression, anxiety, substance abuse and headaches, and processes for preparing such compounds.

Novel Compounds as SMARCA2 Inhibitors for Treating Non-Small Cell Lung Cancer

Abstract Provided herein are novel compounds as SMARCA2 inhibitors, pharmaceutical compositions, use of such compounds in treating non-small cell lung cancer (NSCLE), and processes for preparing such compounds.