Ralf Weberskirch

DNA-encoded Ugi reactions in the organic phase: Lactam synthesis and use of cyclic ketones as scaffold-providing oxo-component

Isocyanide multicomponent reactions such as the Ugi fourcenter reaction are attractive for DNA-encoded library design because they allow for synthesizing diverse peptidomimetic and heterocyclic scaffolds from large numbers of simple and readily available starting materials. DNA a...