Ralf Dietze

ORF7a, Mitochondrial Reprogramming, and Testable Intervention Concepts

A recent cell-model study reports that the SARS-CoV-2 accessory protein ORF7a increases PDK4, inhibits pyruvate dehydrogenase (PDH), impairs mitochondrial Complex I and respiratory-supercomplex organization, increases oxidative stress, and redirects metabolism away from efficient...

ORF7a, Mitochondrial Reprogramming, and Testable Intervention Concepts

A recent cell-model study reports that the SARS-CoV-2 accessory protein ORF7a increases PDK4, inhibits pyruvate dehydrogenase (PDH), impairs mitochondrial Complex I and respiratory-supercomplex organization, increases oxidative stress, and redirects metabolism away from efficient...