Rajeshwar Awatramani

Astrocytes mediate the dopaminergic modulation of tonic GABAergic signaling in substantia nigra

Recent studies have implicated dopaminergic signaling within the substantia nigra pars reticulata (SNr) in the emergence of Parkinsonian motor deficits. To better understand the mechanisms underlying this dependence, the ability of dopamine to modulate SNr neuron activity was stu...

Calbindin stratifies midbrain dopaminergic neurons governing distinct aspects of locomotion

Despite advances in delineating the molecular diversity and projection patterns of midbrain dopamine (DA) neurons, subtype-specific contributions to motor learning and movement execution remain poorly defined. Here, we applied intersectional ablation and inhibitory chemogenetics...