Raimund Dutzler

The intracellular subdomain of the volume-regulated anion channel subunit LRRC8A is a hotspot of channel activation

Abstract Volume-regulated anion channels (VRACs), formed by heteromers of LRRC8 subunits, mediate the transport of anions and organic osmolytes in numerous physiological processes. Although their gating mechanism remains poorly understood, conformational rearrangements of the cyt...