Raffaele Ornello

Abnormal neurovascular coupling in the precuneus–posterior cingulate cortex may bridge simple and complex aura phenomena in the migraine brain

Migraine aura is a heterogeneous phenomenon in which visual symptoms predominate, while a substantial proportion of patients also experience somatosensory and, more rarely, dysphasic or motor manifestations. While neurovascular coupling (NVC) abnormalities within the visual corti...

Costs and use of antimigraine drugs in Italy: a ten-year analysis of national data

Abstract Background Migraine is a highly prevalent neurological disorder associated with substantial disability and economic burden. Considering the recent introduction of anti-calcitonin gene-related peptide (CGRP) monoclonal antibodies (mAbs), expenditure analysis are needed to...

Decoding the causes of ischemic stroke despite ongoing oral anticoagulation and their clinical impact: the ASPERA-R study

BACKGROUND: Oral anticoagulants (OACs), including vitamin K antagonists and direct OACs, reduce stroke risk in atrial fibrillation (AF), yet breakthrough ischemic stroke still occurs in 1-2% of patients annually despite adequate therapy. The mechanisms underlying these events rem...