Rafael Mamede

Molecular mechanism of complement interference by Streptococcus pyogenes nuclease A

Abstract Bacteria deploy virulence factors to subvert host immunity; yet the molecular details of these interactions often remain limited. Here, we reveal the structure and host interactome of the Streptococcus pyogenes nuclease A (SpnA). We characterize the structure and dynamic...

Genomic analysis and clinical characteristics of a seasonal upsurge of Streptococcus pyogenes emm12

Abstract Purpose Streptococcus pyogenes cause invasive infections with variable incidence over time. In 2023, an increase in invasive S. pyogenes infections caused by emm- types 1 and 12 was reported globally. In Southern Sweden an increase in S. pyogenes emm 12 severe infections...