Rafael C. Bernardi

The urinary pathobiont Actinobaculum massiliense can generate androgens via the dirAB pathway

While overlooked during the Human Microbiome Project, characterizing the urinary microbiota in health and disease is a new frontier in microbiome science. Recent studies have associated differential abundance of bacterial taxa including Propionimicrobium lymphophilum and Actinoba...

Mapping of dynamic allostery within p38 alpha kinase via network analyses and NMR spectroscopy

Abstract Kinases are major drug targets especially in cancer therapy. However, the high degree of conservation of their active sites hinders the development of selective inhibitors, motivating a deeper understanding of kinase conformational ensembles and allosteric communication...