Rafael Brüschweiler

GDP-Loaded K-RasTransiently Binds to EffectorB-Raf RBD, Mirroring the Structure of the Active GTP-LoadedComplex

Abstract The Ras-Raf protein association initiates the downstream mitogen-activated protein kinase (MAPK) signaling cascade. This interaction depends on the Ras-nucleotide ligand, whereby Raf preferentially binds to the active guanosine triphosphate (GTP)-loaded state over the gu...