Radoslaw J. Gora

GTPase cycle and ER membrane regulate cargo handover during cotranslational protein targeting

Signal recognition particle (SRP), a universally conserved protein-targeting machine, cotranslationally recognizes signal sequences of nascent endomembrane proteins and engages the SRP receptor (SR) at the endoplasmic reticulum (ER) membrane to unload the translating ribosome. Th...