Radosław Birger

The Role of Non-Coding RNAs in the Pathogenesis of Asthma

Asthma is a chronic inflammatory airway disease characterized by considerable clinical and molecular heterogeneity, involving complex interactions between genetic susceptibility, environmental factors, and immune dysregulation. Increasing evidence indicates that non-coding RNAs (...

Genetic Polymorphisms in Rheumatoid Arthritis: From GWAS-Identified Loci to Functional, Biomarker, and Pharmacogenomic Insights

Rheumatoid arthritis (RA) is a chronic autoimmune disease with a complex, multifactorial aetiology, in which both environmental factors and genetic predisposition play a significant role. This narrative review summarises the genetic polymorphisms associated with RA that have been...

Drug-based ionic derivatives of NSAIDs: influence of cation structure on physicochemical properties, skin permeation, and biocompatibility

Abstract Drug-based ionic systems represent a promising strategy to improve the physicochemical properties and delivery performance of poorly soluble active pharmaceutical ingredients. In this study, ionic derivatives of four nonsteroidal anti-inflammatory drugs (NSAIDs)—ibuprofe...