Rachel N. Grisham

DUSP4 overexpression is associated with MAPK pathway alterations in low-grade serous ovarian cancer

MAPK pathway alterations, most commonly KRAS , NRAS , and BRAF mutations, occur in approximately 50–60% of ovarian low-grade serous carcinomas (LGSCs). We sought to identify clinically translatable markers of MAPK pathway activation in LGSC samples. Differential gene expression a...