Author
Rachel Molino
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Recent research
- Materials & Energy
Fluorine-InducedElimination Drives Mechanism-BasedInactivation of Isocitrate Lyase
Abstract Fluorinated succinate analogues were evaluated as mechanistic probes of Mycobacterium tuberculosis isocitrate lyase (MtICL). However, 2,2-difluorosuccinate (1; Ki = 6.1 mM) and 2,2,3-trifluorosuccinate (2; Ki = 23.5 μM) act as reversible noncompetitive inhibitors and mes...