Qunfang Zhou

Metal–Organic Framework MIL-101 Induces Macrophage Ferroptosis through Depriving Cystine Uptake and Overloading Labile Iron Pool

Abstract The wide applications of metal–organic frameworks (MOFs) in environmental remediation and biomedicine inevitably lead to their entry into the environment and human body, exerting unexpected risks. Recent studies have primarily focused on the cytotoxicity testing of MOFs;...

Toxicokinetics, Biotransformation, and Tissue Distribution of Imidaclothiz in Rats

Abstract Imidaclothiz (IMZ), a next-generation neonicotinoid pesticide, has garnered significant attention due to its detection in human samples. In this study, we investigated its toxicokinetics and biotransformation in rats following oral administration. IMZ was rapidly absorbe...

Structure-Related Activity of 4-Alkylphenols in Hepatic Lipogenesis Regulated by Estrogen Receptor Agonism and Oxidative Stress

Abstract 4-Alkylphenols (APs), as typical endocrine-disrupting chemicals (EDCs) widely present in the environment and the human body, have been implicated in the disruption of lipid metabolism. However, the structure-activity relationships (SARs) and underlying mechanisms of thei...