Quan Yuan

Disclosing Structural Determinants Governing Stereopreferences of Ketoreductases toward Reduction of Halogenated Aryl Ketones

Abstract Ketoreductases (KREDs) are widely used for asymmetric ketone reduction, yet predictable control of stereoselectivity remains challenging due to the limited understanding of structure–selectivity relationships. Here, we integrate site-directed mutagenesis and molecular dy...

MWMOTE-MLLM: A cluster-level difficulty-aware oversampling multimodal large language model framework for imbalanced fault diagnosis of rolling bearings in horizontal reactors

The horizontal reactor serves as a critical piece of equipment in petrochemical production and operates under extreme conditions, including high temperature, high pressure, and strong corrosion. Under such conditions, rolling bearings are prone to faults caused by excessive vibra...