Qizhu Chen

Persistent Zn 2+ Influx‐Mediated Deacetylation of ANXA2 Regulates the “Zn 2+ ‐Autophagic Flux” and Alleviates Intervertebral Disc Degeneration

ABSTRACT Intervertebral disc degeneration (IVDD) is an age‐related disease accompanied by disrupted mitochondrial homeostasis and defective autophagy. Cellular senescence induces ion imbalance, which leads to mitochondrial damage and suppressed autophagic flux; nevertheless, the...

Ginsenoside Rh2 Attenuates Intervertebral Disc Degeneration by Modulating the PI3K/AKT Signaling Pathway to Suppress Apoptosis

Intervertebral disc degeneration (IVDD) is a major cause of chronic low back pain and imposes a substantial socioeconomic burden. Ginsenoside Rh2 (Gin-Rh2), a bioactive ginseng compound with antioxidant properties, may have therapeutic potential in IVDD, but its effects and under...