Qiyue Zhu

Interferon Regulatory Factor 1 Inhibits the Adipogenic Differentiation of BMSCs via the AMPK – mTOR Signaling Axis and Induces Their Autophagy to Alleviate Osteoporosis‐Related Bone Marrow Adiposity

ABSTRACT Increased bone marrow adiposity is a characteristic of osteoporosis and negatively regulates osteogenesis. Bone marrow mesenchymal stem cells (BMSCs) give rise to bone marrow adipocytes. The transcription factor interferon regulatory factor 1 (IRF1) modulates multiple bi...