Qing Lou

Encapsulation of AAVs into Protein Vault Nanoparticles as a Novel Solution to Gene Therapy’s Neutralizing Antibody Problem

Abstract Although adeno-associated virus (AAV) has enjoyed enormous success as a delivery modality for gene therapy, it suffers from high prevalence of preexisting neutralizing antibodies in human populations, limiting who can receive potentially life-saving treatments. As a nove...

Solid‐Phase Engineered Metal‐Free Carbonized Polymer Dots With Auto‐Generated Rigid Amorphous Network Enabled High‐Temperature Liquid‐Phase Phosphorescence

While organic phosphorescent materials hold immense promise, their application is severely hampered by limited emission tunability, short lifetimes, and environmental instability. Herein, we report a facile solid-phase engineering strategy to achieve the large-scale synthesis of...