Qilei Zhu

Diastereo- and Enantioselective Photobiocatalytic α-Alkylation of α-Heteroaryl Amines Enabled by Pyridoxal Photochemistry

Abstract We report a photobiocatalytic system for the enantio- and diastereoselective α-alkylation of α-heteroaryl amines, a largely underexplored class of synthetically valuable non-native amine donors. Evaluation and directed evolution of thermophilic threonine aldolases, enabl...