Qiaodan Ou

Deletion of the T1D risk gene Ormdl3 in β-cells does not impact disease progression

Orosomucoid-like (ORMDL) proteins are a component of the serine palmitoyltransferase complex and a negative regulator of ceramide synthesis. Among these ORMDL3 in addition to its role in lipid homeostasis, plays a key role in inflammation, endoplasmic reticulum stress, and immune...