Qiangping Zhou

Ceruloplasmin deficiency promotes osteoclast cuproptosis-like cell death and is associated with higher bone mass in OVX mice with coordinated activation of AMPK/p53 signaling

Abstract Osteoclast bone resorption consumes a large amount of energy, and its energy metabolism disorder is an important pathogenesis of bone metabolism diseases such as osteoporosis. Excessive copper ions interfere with the energy metabolism of the mitochondrial tricarboxylic a...