Qiang Wang

Therapeutic Targeting of the Macrophage YTHDC1/TIGAR/NF-κB Axis Mitigates Pulmonary Hypertension

Abstract Rationale Immune dysregulation is a pivotal driver of pulmonary hypertension (PH) pathogenesis, yet therapeutic targeting of inflammation has yielded limited clinical success. Although cytosolic RNA-binding proteins are known to regulate immune responses in PH, the speci...

Wnt2bb-triggered neighbor cell proliferation is essential for cloaca formation by inducing apoptosis in the cloaca through cell competition

Cloaca serves as the only opening for the digestive, urinary, and reproductive tracts in multiple species. Apoptosis is crucial for shaping the cloaca, yet the underlying mechanisms remain largely unclarified. Here we find that Wnt2bb-triggered neighbor cell proliferation is esse...

TM184C is a GPCR-like regulator of intercellular exchange and autophagy

Sequence similarity underlies most protein annotation, yet many functions remain hidden beyond detectable homology1–3. By mining millions of AlphaFold2 models4,5, we identify two human families of ‘superdark’ seven-transmembrane proteins—TM184 and PRRT—with structural homology to...