Qi zhang

Hepatocyte OTUD1 promotes hepatic stellate cell activation and liver fibrosis by stabilizing HSP90β

Crosstalk between parenchymal and nonparenchymal cells of the liver mediates the activation of hepatic stellate cells (HSCs). Activated HSCs transform into myofibroblasts and produce the extracellular matrix (ECM), and massive ECM accumulation can affect liver function and eventu...