Qi Pan

Effectiveness and clinical characteristics of biologic switching in severe asthma patients with inadequate response to initial biologic therapy: a systematic review

Bronchial asthma (hereafter referred to as asthma) is a common chronic inflammatory airway disease affecting more than 300 million people worldwide. Although most patients achieve control with conventional or biologic therapies, a subset of patients with severe asthma has an inad...

IL10RB-AS1 promotes pro-caspase-1-dependent pyroptosis via regulating the oligomerization and nucleation of CARD8 C-terminal domain to suppress acute myeloid leukemia

Abstract CARD8 (caspase activation and recruitment domain-containing 8) senses intracellular danger signals, leading to inflammasome formation and pyroptosis. Recently studies have shown that CARD8 was highly expressed in hematopoietic cells, however, the mechanism by which the r...