Qi Gao

A spatiotemporally programmed bioactive scaffold for orbital reconstruction

Orbital implants are widely used for post-enucleation reconstruction, but poor fibrovascularization and infection risk still limit their clinical performance. Herein, a three-dimensional (3D)-printed copper-doped hardystonite (HT, Ca 2 ZnSi 2 O 7 ) scaffold with polar-graded poro...

A Metabo‐Reprogramming Niche Remodeling System Halts Osteoarthritis by Restoring the FGF21‐Arginine Axis

Osteoarthritis (OA), a global leading cause of chronic pain and disability, lacks disease-modifying osteoarthritis drugs (DMOADs) targeting its core pathogenesis. scRNA-seq of human OA cartilage showed marked depletion of a high-arginine-metabolism chondrocyte subpopulation drivi...